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Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis

NCT04864392

TerminatedPhase 2

Sponsor: Novartis Pharmaceuticals

Conditions: Osteoarthritis

Interventions: LNA043, Placebo

Countries: United States, Argentina, Australia, Canada, China, Czechia, Denmark, Estonia

This was a multicenter, randomized, double-blind, placebo-controlled Phase IIb study evaluating intra-articular LNA043 in patients with knee osteoarthritis.

Eligibility overview

Sex: ALL

Age: 40 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Key Inclusion Criteria:

* Males and females between 40 and 75 years of age
* Body mass index (BMI) \< 40 kg/m2
* Diagnosis of primary tibiofemoral knee OA by standard American College of Rheumatology clinical and radiographic criteria

Key Exclusion Criteria:

* Participants with radiographic knee OA K-L grade = 4 on the non-target knee
* Arthroscopy of the target knee within the 6 months prior to Screening
* Hemoglobin \< 8.5 g/dL (85 g/L) or platelet count \< 100,000/μL
Locations (75)
  • Phoenix, Arizona, United States
  • Tucson, Arizona, United States
  • La Mesa, California, United States
  • Lincoln, California, United States
  • Long Beach, California, United States
  • Riverside, California, United States
  • Sacramento, California, United States
  • San Diego, California, United States
  • Stamford, Connecticut, United States
  • Ocoee, Florida, United States
  • Tampa, Florida, United States
  • Winter Park, Florida, United States
  • Chicago, Illinois, United States
  • Marrero, Louisiana, United States
  • Wheaton, Maryland, United States
  • Kansas City, Missouri, United States
  • Hartsdale, New York, United States
  • Knoxville, Tennessee, United States
  • Dallas, Texas, United States
  • Sugar Land, Texas, United States
  • Charlottesville, Virginia, United States
  • Fairfax, Virginia, United States
  • Richmond, Virginia, United States
  • Caba, Argentina
  • Córdoba, Argentina
  • San Miguel de Tucumán, Argentina
  • Broadmeadow, New South Wales, Australia
  • Maroochydore, Queensland, Australia
  • Woodville South, South Australia, Australia
  • Hobart, Tasmania, Australia
  • + 45 more on CT.gov