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Study of the Mechanisms of Action of Cladribine in Multiple Sclerosis

CompletedNA

Sponsor: University Hospital, Rouen

Conditions: Multiple Sclerosis

Interventions: biological collection

Countries: France

The main objective of the project is therefore to study and thus better understand the immunomodulatory / anti-inflammatory effects of cladribine during multiple sclerosis. Most current and developing therapies targeting the immune system have no effect on the progressive phase of MS, during which neurodegeneration plays a predominant role. As mentioned above, the very promising results of clinical trials with cladribine tablets for the early and progressive phase of the disease have revealed immunomodulatory properties and suggested potential neuroprotective effects. It therefore plans to further dissect one of these two parameters by designing in vitro studies with peripheral blood mononuclear cells (PBMC) from healthy donors and MS patients.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Major Multiple Sclerosis (MS) Patients
* RR MS patients without treatment (early stage disease) Or RR MS patients treated with first-line compounds (IFNβ, glatiramer acetate, teriflunomide and dimethyl fumarate, ...).

Or RR MS patients treated with second-line compounds (natalizumab and fingolimod, ...) RR MS patients treated with third-line compounds (alemtuzumab, ...) Or Patients with progressive MS

* Patients who have read and understood the information letter and signed the consent form
* Person affiliated to a social security system

Exclusion Criteria:

* Patients under 18 years of age or over 65 years of age,
* Patients who have benefited from immunosuppressive treatments for other autoimmune or cancerous pathologies,
* Patients receiving treatments for multiple sclerosis and participating in phase 2, 3 or 4 protocols will be excluded.
* Patients who have been treated for less than 1 year with cladribine, daclizumab, ocrelizumab, rituximab will be excluded.
* Patients who have received mitoxantrone or a stem cell transplant,
* Regulatory Criteria :
* Person deprived of liberty by an administrative or judicial decision
* Person placed under legal protection, sub-tutorship or curatorship

Locations (1)

Rouen, France