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Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences

NCT04819737

RecruitingNA

Sponsor: University Hospital, Basel, Switzerland

Conditions: Multiple Sclerosis (MS)

Interventions: SC MRI, patient questionnaire

Countries: Switzerland

This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Diagnosis of multiple sclerosis according to established international criteria
* Steroid free period: \> 4 weeks
* Participation in the Swiss MS Cohort (SMSC) study

Exclusion Criteria:

* . History of severe (other) neurological, internal or psychiatric disease with SC affection
* MRI-related exclusion criteria (questionnaire):

  1. Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC)
  2. Pacemaker
  3. Claustrophobia
  4. Pregnancy, lactation
  5. Known hypersensitivity to gadolinium-based contrast media

Locations (1)

Basel, Switzerland