NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

NCT04793958

Active Not RecruitingPhase 3

Sponsor: Mirati Therapeutics Inc.

Conditions: Advanced Colorectal Cancer, Metastatic Colorectal Cancer

Interventions: MRTX849, Cetuximab, mFOLFOX6 Regimen, FOLFIRI Regimen

Countries: United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, China

Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
* Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria:

* Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
* Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
* Active brain metastasis

Locations (419)

Alabaster, Alabama, United States
Bessemer, Alabama, United States
Birmingham, Alabama, United States
Birmingham, Alabama, United States
Birmingham, Alabama, United States
Birmingham, Alabama, United States
Birmingham, Alabama, United States
Gilbert, Arizona, United States
Goodyear, Arizona, United States
Phoenix, Arizona, United States
Springdale, Arkansas, United States
Bakersfield, California, United States
Chula Vista, California, United States
Fresno, California, United States
Fullerton, California, United States
La Mesa, California, United States
Los Angeles, California, United States
Los Angeles, California, United States
Los Angeles, California, United States
Newport Beach, California, United States
Redlands, California, United States
San Diego, California, United States
San Diego, California, United States
San Diego, California, United States
San Francisco, California, United States
Santa Monica, California, United States
Sylmar, California, United States
Torrance, California, United States
Whittier, California, United States
Aurora, Colorado, United States
+ 389 more on CT.gov