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Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer

Active Not RecruitingNA

Sponsor: Emory University

Conditions: Colon Cancer, Obesity

Interventions: High Fiber Diet Featuring Legumes (HLD), Healthy American Diet

Countries: United States

This study tests whether a high-fiber diet based on legumes, such as dry beans, can lead to sustained reductions in obesity and colon cancer risk in persons at highest risk, namely overweight or obese, post-polypectomy patients.

Eligibility overview

Sex: ALL

Age: 40 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* free-living adults 40 to 75 years old
* BMI 25-40 kg/m\^2
* able to provide documentation confirming a colonoscopy within 3 years that found ≥1 adenoma \>0.5 cm or a sessile serrated polyp (any)
* English speaking
* ambulatory, able to pick up food, participate in clinical exams and laboratory tests
* able to provide informed consent

Exclusion Criteria:

* serious and/or unstable medical condition as deemed by study physician
* history of colorectal cancer, bowel resection, polyposis syndrome, or inflammatory bowel disease
* smoked regularly in the past year
* dietary restrictions substantially limiting compliance (e.g., must be willing to be randomized to either diet)
* planning on substantially changing usual exercise behavior in the next 6 months
* regular or recent use of prescription medication that may alter inflammation markers or gut function as deemed by study physician
* pregnant women, breast feeding women, or women planning pregnancy within the year of active study participation

Locations (1)

Atlanta, Georgia, United States