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Inclusion Criteria:

* Histologically- or cytologically-documented ES-SCLC (stage IV \[T any, N any, M1 a/b\], or with T3-4 due to multiple lung nodules that are too extensive or have tumor/nodal volume that is too large to be encompassed in a tolerable radiation plan (Brain metastases; must be asymptomatic or treated and stable off steroids and anticonvulsants for at least 1 month prior to study treatment)
* Participants must be considered suitable to receive a platinum-based chemotherapy regimen as 1st line treatment for the ES-SCLC. Chemotherapy must contain either cisplatin or carboplatin in combination with etoposide
* World Health Organization/ Eastern Cooperative Oncology Group performance status of 0 to 2 at enrollment Baseline computed tomography/ magnetic resonance imaging results of the brain, chest and abdomen (including liver and adrenal glands) within 28 days prior to the treatment initiation
* No prior exposure to immune-mediated therapy including, but not limited to, other anti- CTLA-4, anti-Programmed cell death-1 (PD-1), anti- Programmed cell death ligand-1 (PD-L1), and anti-PD-L2 (anti-PD-L2) antibodies, excluding therapeutic anticancer vaccines
* Adequate organ and marrow function
* Body weight \> 30 kg
* Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal participants

Exclusion Criteria:

* History of allogeneic organ transplantation
* Active or prior documented autoimmune or inflammatory disorders, systemic lupus erythematosus, sarcoidosis syndrome, or wegener syndrome
* Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, uncontrolled cardiac arrhythmia, active interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the participant to give written informed consent
* History of another primary malignancy except for:

  * Malignancy treated with curative intent and with no known active disease ≥ 5 years before the first dose of Investigational medicinal product (IMP) and of low potential risk for recurrence
  * Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease
  * Adequately treated carcinoma in situ without evidence of disease
* History of leptomeningeal carcinomatosis and active primary immunodeficiency
* Active infection including tuberculosis, hepatitis B, hepatitis C, human immunodeficiency virus
* Any unresolved toxicity Common Terminology Criteria for Adverse Events Grade ≥ 2 from previous anticancer therapy
* Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients
* Received prior systemic therapy for ES-SCLC
* Medical contraindication to platinum (cisplatin or carboplatin)-etoposide-based chemotherapy
* Any concurrent chemotherapy, IMP, biologic, or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for non-cancer-related conditions is acceptable
* Planned consolidation chest radiation therapy. Radiation therapy outside of the chest for palliative care is allowed but must be completed before first dose of the study medication
* Receipt of live attenuated vaccine within 30 days prior to the first dose of in IMP
* Major surgical procedure within 28 days prior to the first dose of IMP
* Participants who have received prior immunotherapy agents including anti-PD-1 or anti PD-L1
* Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab
* Participation in another clinical study with an investigational product administered in the last 4 weeks
* Female participants who are pregnant or breastfeeding or male or female participants of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of durvalumab and 180 days after the last dose of etoposide

• Panagyurishte, Bulgaria
• Rousse, Bulgaria
• Sofia, Bulgaria
• Sofia, Bulgaria
• Sofia, Bulgaria
• Montreal, Quebec, Canada
• Burgas, Czechia
• Olomouc, Czechia
• Ostrava, Czechia
• Berlin, Germany
• Berlin, Germany
• Cologne, Germany
• Gauting, Germany
• Hamburg, Germany
• Jena, Germany
• Kassel, Germany
• Ancona, Italy
• Bari, Italy
• Milan, Italy
• Naples, Italy
• Orbassano, Italy
• Palermo, Italy
• Roma, Italy
• Adapazarı, Turkey (Türkiye)
• Ankara, Turkey (Türkiye)
• Ankara, Turkey (Türkiye)
• Ankara, Turkey (Türkiye)
• Antalya, Turkey (Türkiye)
• Bursa, Turkey (Türkiye)
• Edirne, Turkey (Türkiye)
• + 5 more on CT.gov