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Sponsor: Assistance Publique - Hôpitaux de Paris
Conditions: Covid19, SARS-CoV-2
Interventions: Blood count, Blood collection, Nasopharyngeal swab, Saliva samples, Faeces samples
Countries: France
The purpose of this study is to describe the immunological and virological response of patients infected with CoV-2-SARS and presenting an asymptomatic or mildly symptomatic form, in particular the innate and adaptive response as well as the virological clearance kinetics. The research hypothesis is that patients with an ambulatory form of SARS-CoV-2 infection, whether asymptomatic or mildly symptomatic, are able to mount an innate and adaptive immunological response capable of rapidly clearing the virus, in contrast to severe forms in which an early deficit of type 1 IFN response has been demonstrated, possibly responsible for a defect in the control of viral replication in the blood.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Adult patients * Nasopharyngeal PCR positive for SARS-CoV-2 within 48 hours prior to inclusion in the study protocol, carried out in one of the participating outpatient screening centers * Symptomatic patients (nasopharyngeal screening positive due to suggestive symptoms) or asymptomatic (nasopharyngeal screening positive due to screening after contact with a positive subject) * Patients who have been informed and signed the consent * Pregnant and breastfeeding women who may be included in the study. Exclusion Criteria: * Patients with criteria for hospitalization at the time of diagnosis (seriousness criteria, impossibility of staying at home) * Non-consent or inability to obtain consent, * Patient with dementia or not authorized, for psychiatric reasons or intellectual failure, to receive information on the protocol and to give informed consent, * Patient under guardianship / curatorship
- Paris, Île-de-France Region, France