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Defining the Severe Paediatric Asthma Endotype

CompletedNA

Sponsor: Assistance Publique - Hôpitaux de Paris

Conditions: Severe Asthma

Interventions: Blood collection, Saliva sample, Nasal

Countries: France

The primary objective of this project is to extensively characterize the endotypes of pre-schoolers (0 to 6 years) and school-age children (6 to 12 years) with SA using an integrated approach, combining a description of their phenotype (asthma symptoms, atopy, and lung function) associated with histological (airway inflammation and remodelling), immune (innate and adaptive immunity), metabolomics, and microbiota analyses. This goal shall be achieved by an unsupervised in-depth analysis of patients requiring bronchial endoscopy, with bronchial alveolar lavage (BAL) and bronchial biopsy, as part of their clinical assessment.

Eligibility overview

Sex: ALL

Age: — to 12 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Patient Inclusion Criteria:

* Minors aged 0 to 6 years or 6 to 12 years, hospitalized for assessment of Severe Asthma
* Minors need with his follow-up an bronchial endoscopy with realization of LBA and biopsies of bronchial mucosa
* Social insurance affiliation, except AME
* Parents or legal guardians signed the Informed consent form

Control Inclusion Criteria:

* Minors aged 0 to 6 years or 6 to 12 years, hospitalized for assessment of severe respiratory syndrome except severe asthma
* Minors need with his follow-up an bronchial endoscopy with realization of LBA and biopsies of bronchial mucosa
* Social insurance affiliation, except AME
* Parents or legal guardians signed the Informed consent form

Patient Exclusion Criteria

* Prematurity (\<37 weeks gestation)
* Broncho-pulmonary dysplasia, immune deficits, non-Severe Asthma bronchopathies, cystic fibrosis, heart disease, ongoing biotherapy

Locations (1)

Paris, France