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Study To Assess Efficacy, Safety, Tolerability And Pharmacokinetics Of PF-07038124 Ointment In Participants With Atopic Dermatitis Or Plaque Psoriasis
Study To Assess Efficacy, Safety, Tolerability And Pharmacokinetics Of PF-07038124 Ointment In Participants With Atopic Dermatitis Or Plaque Psoriasis

NCT04664153

CompletedPhase 2

Sponsor: Pfizer

Conditions: Atopic Dermatitis, Plaque Psoriasis

Interventions: PF-07038124 ointment, Vehicle ointment

Countries: United States, Australia, Canada, Poland

This study is being conducted to provide data on efficacy, safety, tolerability and PK of PF-07038124 ointment versus vehicle control in the treatment of mild to moderate AD and mild to moderate plaque psoriasis.

Eligibility overview

Sex: ALL

Age: 18 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Atopic Dermatitis (AD): Have been diagnosed with AD for at least 3 months; Have an Investigator's Global Assessment (IGA) score of 2 (mild), or 3 (moderate); Have AD covering 5% to 20% (inclusive) of BSA.
* Plaque psoriasis: Have been diagnosed with plaque psoriasis (psoriasis vulgaris) for at least 6 months; Have a Physician Global Assessment (PGA) score of 2 (mild), or 3 (moderate); Having plaque psoriasis covering 5% to 15% (inclusive) of BSA.

Exclusion Criteria:

* Presence of skin comorbidities that would interfere with study assessment or response to treatment.
* Current or recent history of severe, progressive, or uncontrolled renal, hepatic, hematological, gastrointestinal, metabolic, endocrine, pulmonary, cardiovascular, or neurological disease.
* Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
Locations (29)
  • Fountain Valley, California, United States
  • Cape Coral, Florida, United States
  • Clearwater, Florida, United States
  • Doral, Florida, United States
  • Orlando, Florida, United States
  • Tampa, Florida, United States
  • Indianapolis, Indiana, United States
  • Plainfield, Indiana, United States
  • Detroit, Michigan, United States
  • Raleigh, North Carolina, United States
  • Portland, Oregon, United States
  • Memphis, Tennessee, United States
  • Cypress, Texas, United States
  • Houston, Texas, United States
  • Webster, Texas, United States
  • Maroubra, New South Wales, Australia
  • Camberwell, Victoria, Australia
  • Hamilton, Ontario, Canada
  • Markham, Ontario, Canada
  • Mississauga, Ontario, Canada
  • Montreal, Quebec, Canada
  • Québec, Canada
  • Bialystok, Poland
  • Grodzisk Mazowiecki, Poland
  • Katowice, Poland
  • Lodz, Poland
  • Ostrowiec Świętokrzyski, Poland
  • Rzeszów, Poland
  • Warsaw, Poland