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Hyperpolarized 129Xe MRI of Survivors of COVID-19

CompletedPhase 1

Sponsor: University of Kansas Medical Center

Conditions: Covid19

Interventions: Hyperpolarized Xe129

Countries: United States

The purpose of this study is to evaluate pulmonary function of patients recovering from mild, moderate, and severe COVID-19 disease using hyperpolarized 129Xe MRI.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Oxygenation saturation of ≥88% at rest by study staff within 48 hours prior to study entry.
* The participant has a previous diagnosis of COVID-19 confirmed by COVID-19 PCR or antibody testing and is being seen for outpatient follow-up.
* Subject is at least 10 days post-symptom-onset and do not have a fever (\<99.5°).
* Ability to read and understand English or Spanish

Exclusion Criteria:

* Subject is less than 18 years old
* MRI is contraindicated based on responses to MRI screening questionnaire
* Subject is pregnant or lactating
* Subject does not fit into 129Xe vest coil used for MRI
* Subject cannot hold his/her breath for 15-16 seconds
* Subject deemed unlikely to be able to comply with instructions during imaging
* Oxygen saturation \<88% on room air or with supplemental oxygen
* Cognitive deficits that preclude ability to provide consent
* Institutionalization

Locations (1)

Kansas City, Kansas, United States