NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

The Impact of Oral Health in HIV Patients on Antiretroviral Therapy

CompletedN/A

Sponsor: University of Pennsylvania

Conditions: HIV, Periodontal Diseases, Caries, Non-communicable Disease, Xerostomia

Countries: United States

This is a prospective cohort study designed to investigate the range of metabolic abnormalities observed in patients living with HIV on antiretroviral therapy. This study will also explore the concurrent role of poor oral health in supporting and driving chronic immune activation and inflammation in HIV infection.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Age ≥18 years
* Has been diagnosed with HIV (as documented by a prior laboratory report of positive HIV-1/2 antibody and/or detectable HIV RNA, available for review by the study team)
* Has received antiretroviral therapy for at least 12 months
* Able and willing to provide informed consent prior to initiation of study procedures
* Willing and able to comply with all study procedures, and likely to be available for the duration of the study

Exclusion Criteria:

* Has been diagnosed with the following xerostomia-related autoimmune conditions: Sjorgen's and sarcoidosis
* Has never received radiation therapy to the head or neck (including radioactive iodine therapy)
* Was taking anti-osteoporotic agents (biphosphonates, denosumab) prior to HIV diagnosis.
* Women who are pregnant at the time of enrollment.

Locations (1)

Philadelphia, Pennsylvania, United States