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Bone Erosions in Rheumatoid Arthritis - Characterization Evaluated by Imaging and Histology

Active Not RecruitingN/A

Sponsor: University of Aarhus

Conditions: Arthritis, Rheumatoid

Countries: Denmark

The aim of this study is to describe macro- and micro anatomical structures, including investigating vessels running in osseous pores in finger joints from participants with rheumatoid arthritis (RA) using histology and different imaging modalities. The perspectives are to increase understanding of the macro- and micro anatomic basis for bone erosions in RA, and possibly to provide new insights to the monitoring of patients with RA.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

RA Participants:

Inclusion Criteria:

* Age \> 18 years
* Participants diagnosed with RA according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010.
* Indication for prosthesis surgery with total joint replacement of the MCP joint according to the clinical procedure (often radiological signs of OA in the MCP joint, joint pain, angular deformity and/or impairment of daily functions).

Exclusion Criteria:

* Unable to give written informed consent.
* Active malignant disease, hypercalcemia, poor kidney function (estimated glomerular filtration rate \< 35 mL/min), untreated hypo-/hyperthyroidism, pregnancy or wish thereof, previously fracture/dislocation of the investigated joint or metal prosthesis in joints of the investigated hand.

Bone sample will be excluded from analysis, if the following is present:

\- Bone not adequate for analysis (fractured bone samples).

Locations (2)

Aarhus, Central Region of Denmark, Denmark
Holstebro, Central Region of Denmark, Denmark