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Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

NCT04634643

RecruitingN/A

Sponsor: Yale University

Conditions: NAFLD

Interventions: Usual diet and physical activity

Countries: United States

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

Eligibility overview

Sex: ALL

Age: 12 Years to 18 Years

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Good general health, taking no medication on a chronic basis;
* age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
* BMI \>85th for obese cohort;

Exclusion Criteria:

* Baseline creatinine \>1.0 mg; pregnancy;
* the presence of endocrinopathies (e.g. Cushing syndrome);
* cardiac or pulmonary or other significant chronic illness;
* adolescents with a psychiatric disorder or with substance abuse;
* monogenic obesity syndromes;
* use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).

Locations (1)

New Haven, Connecticut, United States