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Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

RecruitingPhase 1

Sponsor: Mario Castro, MD, MPH

Conditions: Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis, Pulmonary Hypertension

Interventions: Hyperpolarized Xe129

Countries: United States

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Eligibility overview

Sex: ALL

Age: 3 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

Healthy Volunteers:

* Subject has no diagnosed pulmonary conditions
* Ability to read and understand English or Spanish

Subjects with Lung Disease:

* Subject has a diagnosis of pulmonary dysfunction made by a physician
* No acute worsening of pulmonary function in the past 30 days
* Ability to read and understand English or Spanish

Exclusion Criteria:

* MRI is contraindicated based on responses to MRI screening questionnaire
* Subject is pregnant or lactating
* Subject does not fit into 129Xe vest coil used for MRI
* Subject cannot hold his/her breath for 15-16 seconds
* Subject deemed unlikely to be able to comply with instructions during imaging
* Oxygen saturation \<88% on room air or with supplemental oxygen
* Cognitive deficits that preclude ability to provide consent
* Institutionalization

Locations (1)

Kansas City, Kansas, United States