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Inclusion Criteria:

* Mens who have sex with mens (MSM) enrolled in the ANRS PREVENIR study.
* At least 6-month experience with PrEP (within the ANRS PREVENIR study or before starting the ANRS PREVENIR study).
* No clinical manifestation of primary HIV infection and no symptom of bacterial STI (chlamydia, gonorrhea, M. genitalium or syphilis).
* History of documented bacterial STI with at least one episode in the last 12 months.
* Participants who agree to sign the information and consent form specific to this study.
* Valid health insurance (State medical aid (AME) is not health insurance).

Exclusion Criteria:

* Syphilis diagnosed prior to inclusion without serologic evidence of cure (cure is defined as decreased by at least 4-fold of the non-treponemal antibody titer \[Venereal Disease Research Laboratory (VDRL), Rapid Plasma Reagin (RPR)\] relative to the titer at initiation of treatment of syphilis).
* HIV infection.
* Previous vaccination with Bexsero® or any other meningococcal B vaccine.
* Vaccination during the 4 weeks (28 days) preceding the first vaccination of the study.
* Previous vaccination with an experimental vaccine in the previous 5 years.
* Systemic treatment with retinoids : isotretinoin (Acnetrait®, Procuta®, Curacné®, Contracné®, …).
* Treatment with enzyme-inducing anticonvulsants (carbamazepine, phenobarbital, phenytoin, ….).
* Participant who has received immunoglobulins, a transfusion of blood or blood derivatives in the last 3 months.
* Known or suspected congenital or acquired immunodeficiency; immunosuppressive treatment in the last 6 months, such as cancer chemotherapy or radiotherapy; long-term systemic corticosteroid therapy (prednisone or equivalent for more than 2 consecutive weeks in the last 3 months)
* Known allergy to antibiotics of the tetracycline family.
* Known allergy to any component of the Bexsero® vaccine.
* Known allergy to any component of the doxycycline pill.
* Known allergy to latex (contained in the vaccine cap).
* Thrombocytopenia or any other known coagulation disorder, which would be a contraindication to an intramuscular injection of Bexsero® vaccine.
* Documented oesophageal lesion
* Acute respiratory infection or severe acute febrile illness or systemic reaction that may present a significant risk if vaccinated in the month prior to inclusion.
* Any condition (clinical) that, in the investigator's opinion, would contraindicate intramuscular vaccination and blood sampling.
* Oral Anticoagulant treatment.
* Continuous treatment with doxycycline at inclusion.
* Vitamin A treatment in case of intake of 10 000 international unit or more.
* Participation in another research including an exclusion period still in progress at the time of inclusion.
* Under guardianship or curator, or deprived of liberty by a judicial or administrative decision.

• Paris, France
• Paris, France
• Paris, France
• Paris, France
• Paris, France
• Paris, France
• Paris, France
• Paris, France
• Paris, France