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Impact of a Monoamine Oxidase Inhibitor on the Phenotype of Blood Mononucleated Cells in Patients With COVID-19

CompletedN/A

Sponsor: Assistance Publique - Hôpitaux de Paris

Conditions: SARS-CoV2 Infection

Interventions: blood sample

Countries: France

The principal objective is to determine the impact of phenelzine on the activation phenotype of T cells and myeloid cells during SARS-CoV2 infection

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* 1\. Individuals male or female ≥18 years of age at time of enrolment
* 2.Subject (or legally authorized representative provides non opposition form prior to initiation of any study procedure.
* 3\. Understands and agrees to comply with planned study procedure. (Agrees to the collection of venous blood per protocol).
* 4\. Has laboratory-confirmed SARS-CoV-2 infection as determined by PCR, or other commercial or public health assay in any specimen\<72hours prior to enrollment and/or a chest CT scan reported as highly likely SARS-CoV2 infection.

The different scales for severity are as follows:

* 5\. Non severe patients: Clinical assessment (evidence of rales/crackles on exam) or CT scan involvement AND SpO2\> 94% on room air, or ≤ 94% on room air but \> 94% with nasal Oxygen with a flow rate \<= 3l O2/min

For the severe infection's patients' group:

* 6\. Patients requiring mechanical ventilation and/or supplemental oxygen \>= 6l O2/min

For the obese patients 'group:

* 7\. Obese patients will be defined as an BMI \> 30
* 8\. Co inclusion in non-interventional researches is possible

Exclusion Criteria:

* Pregnant and breast-feeding women
* Patients previously treated by phenelzine (Nardil®)
* Persons unable to give their no opposition
* Persons under guardianship or curatorship
* No affiliated to social insurance.
* Inclusion in interventional researches

Locations (1)

Le Kremlin-Bicêtre, France