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SarS-Cov-2 Viral Infection (COVID-19) in Patients With Chronic Inflammatory Rheumatism

TerminatedNA

Sponsor: Assistance Publique - Hôpitaux de Paris

Conditions: Spondyloarthritis, Rheumatoid Arthritis, Covid19

Interventions: blood tests, Nasopharyngeal swabs, Stools

Countries: France

The purpose of this study is to assess whether immunosuppressive therapies used by patients with chronic inflammatory rheumatic diseases have an impact on the viral load and the humoral and cellular responses during viral infection with SarSCoV2, compared to members of their family cluster infected with the same viral strain.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

cases

* Patient with spondyloarthritis fulfilling the ASAS criteria
* Patients with rheumatoid arthritis fulfilling the ACR/EULAR criteria and
* Immunosuppressive therapy: Methotrexate, leflunomide, anti-TNF, Anti-IL6R, abatacept, rituximab, Jak inhibitors (tofacitinib or baricitinib) And
* infected with the SarS-Cov-2 (positive PCR and/or serology and/or CT-scan)

Controls:

* Family cluster member confined to the same location as the index subject
* Infected with the SarS-Cov-2 (positive PCR and/or serology and/or CT-scan)

Exclusion Criteria:

cases and controls

* Pregnant woman
* Breastfeeding woman
* Immunosuppressed subject for members of the familiar cluster of the index subject
* Patient with no social security
* Patients whose freedom is limited by the judicial or administrative authority
* Patients under legal protection

Locations (1)

Paris, France