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Sponsor: Brigham and Women's Hospital
Conditions: Body Weight
Interventions: Maintain usual SSBs, Substitute to non-SSBs, Study app, Beverage delivery
Countries: United States
Sugar-sweetened beverages (SSBs) contribute an alarming \~7% of calories in the US diet among adults, making SSBs the single largest source of added sugar. However, whether artificially sweetened beverages are a healthful alternative for reducing SSB intake among habitual SSB consumers is unknown. Therefore, the investigators will conduct a 4-arm randomized diet intervention trial to test the effects of substituting SSBs with calorie-free alternatives on body weight and health, among habitual SSB consumers with overweight/obesity.
Sex: ALL
Age: 20 Years to 69 Years
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: 1. Adults aged 20-69 years 2. Consume ≥1 serving/day (12 oz.) of SSBs (SSBs include soda, fruit drinks, energy drinks, sports drinks, and sweetened waters, sweetened with high fructose corn syrup, sucrose, or fruit juices. SSBs do not include 100% fruit juice, sweetened teas, or flavored milk.) 3. BMI 25.0 to 45.0 kg/m2 4. Access to a smartphone and willingness and ability to download study app 5. Willing to consume beverages consistent with any of the 4 possible group assignments for 6 months Exclusion Criteria: 1. Physician diagnosis of T2D or fasting glucose ≥126 mg/dL at in-person screening visit 2. Intention to move away from greater Boston area within 1 year from randomization 3. Major medical illness (known cardiovascular disease, cancer, kidney disease, cirrhosis, etc.) 4. Phenylketonuria (PKU) 5. Medication that may affect weight or other study endpoints 6. Another family or household member participating in the study 7. Pregnant in the past 12 months, currently breastfeeding, or planning to become pregnant during the study period
- Boston, Massachusetts, United States