NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

Aerobic Exercise for Remyelination in Multiple Sclerosis

CompletedPhase 1, Phase 2

Sponsor: Oregon Health and Science University

Conditions: Multiple Sclerosis, Sclerosis, Demyelinating Diseases, Autoimmune Diseases of the Nervous System, Nervous System Diseases

Interventions: Aerobic exercise, Education Group Control

Countries: United States

This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).

Eligibility overview

Sex: ALL

Age: 18 Years to 64 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Physician-confirmed diagnosis of MS based on the 2017 McDonald criteria
* 18-64 years old
* Have access to the internet and a device that can access virtual visits
* (Inclusion criteria to advance to clinical trial) Somatosensory evoked potential (SSEP) latency z-score ≥2 for P40 or inter-side difference in z-score ≥2 for P40

Exclusion Criteria:

* Medical or biophysical conditions that prohibit the use of a cycle ergometer or treadmill (medical readiness to be assessed by the Activity Readiness Questionnaire (PAR-Q)) or achievement of target heart rate.
* Engages in \>30 minutes/week of aerobic activity regularly.
* Clinically confirmed MS relapse in the last 3 months.
* Changes in disease modifying therapy (DMT) for MS in the last 6 months.
* Pregnant women.
* Treatment with steroids for MS in the last 30 days.
* Concurrent use of 4-aminopyridine or dalfampridine (medications which can alter SSEP) and unwilling to discontinue it for 2 days prior to SSEP testing.
* Have a known history of severe spinal canal stenosis

Locations (1)

Portland, Oregon, United States