NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

SPINCOMS Biomarker Study

CompletedN/A

Sponsor: Washington University School of Medicine

Conditions: Multiple Sclerosis

Countries: United States

To determine if biomarker-based CSF testing is reliably detecting differences between patients with Multiple Sclerosis (MS), different MS-subtypes, and other central nervous system (CNS) diseases. This study will also look to identify biomarkers that could be used for the prediction, at the time of diagnosis, of the future disease clinical course and response to therapy. The SOMAscan assay will be used for CSF samples analysis.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

MS Patients selection criteria

* Lumbar puncture (LP) in the untreated stage with cryopreserved CSF (serum/blood optional) with consent to use it for future research
* ≥ 3 and ≤ 10 years of follow-up from LP
* At time of LP untreated and not treated with steroid or off steroids ≥ one month
* Available/willing to come for in-person follow-up
* Available/willing to sign the NIH 09-I-0032 "Sample processing only" consent form
* Diagnosis of MS based on 2017 McDonald criteria at time of follow-up visit

Non-MS Patients selection criteria Required: 25 Non-Inflammatory Neurological Disease (NIND), 25 Other Inflammatory Neurological Disease (OIND)

* Lumbar puncture (LP) in the untreated stage with cryopreserved CSF (serum/blood optional) with consent to use it for future research
* ≥ 3 and ≤ 10 years of follow-up from LP
* At time of LP untreated and not treated with steroid or off steroids ≥ one month
* Up to date contact information
* Available/willing to sign the NIH 09-I-0032 "Sample processing only" consent form
* Diagnosis:

NIND: e.g., ischemic-gliotic changes, CADASIL and other leukodystrophies, migraines, ischemic spinal cord lesions etc OIND: e.g. CNS Sjogren's, SLE, vasculitis, CNS infections, MOG-associated disorders, NMO spectrum disorders (NMOSD)

Locations (1)

St Louis, Missouri, United States