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Evaluation of the Reproducibility of the Measurement of the QSM Signal (Quantitative Susceptibility Mapping)

TerminatedN/A

Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Conditions: White Matter Hyperintensity, Multiple Sclerosis

Interventions: MRI

Countries: France

Many central nervous system pathologies have an inflammatory component, often associated with an accumulation of disability and more severe tissue damage. In multiple sclerosis, the inflammatory process is in part characterized by the activation of microglia, an entity of the innate inflammatory system, as well as a breakdown of the blood-brain barrier. During inflammation, activated microglia may contain high levels of iron, characterizing its activated state.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Subject over 18 years old
* Consent to participate in the study
* Beneficiary of a social protection scheme
* Healthy volunteers: Consent to be informed if an unexpected anomaly is revealed by the imagery.
* Patients: With MS defined according to McDonald's revised criteria for spatial dissemination and temporal or clinical or radiological temporal dissemination and who should benefit from MRI in the imaging department

Exclusion Criteria:

* Absolute contraindication to 3T MRI
* Realization of an injected MRI (gadolinium) in the previous year
* Patient benefiting from a legal protection measure
* Pregnant or breastfeeding woman
* For healthy volunteers: History of neurological pathology or neurological pathology in progress

Locations (1)

Paris, France