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Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.

CompletedN/A

Sponsor: Instituto Valenciano de Infertilidade de Lisboa

Conditions: Infertility, Female, First Trimester Spontaneous Abortion

Interventions: Blood samples collection

Countries: Portugal

This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting. It is hypothesized that a robust algorithm including one or more of these biomarkers may allow for the accurate same-day distinction between women with a low and high risk of a spontaneous miscarriage.

Eligibility overview

Sex: FEMALE

Age: 18 Years to 48 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Age: ≥18 and \<49 years old
* Body Mass Index (BMI): ≥18.5 Kg/m2 and \<30 Kg/m2
* Pregnancy resulting from Assisted Reproductive Technologies (ART)
* Single blastocyst transfer pregnancy
* Pregnancy confirmed by blood test
* Gestational age \< 6 weeks at the first US
* Signed and dated informed consent

Exclusion Criteria:

* Spontaneous pregnancies
* Treatment for prevention of miscarriage (i.e. corticoids, aspirin, heparin)
* Those unable to provide the 11th-13th week ultrasound report
* Those unable to comprehend the investigational nature of the proposed study

Locations (1)

Lisbon, Portugal