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Combined Sensitivity and Specificity of Cortical Lesions and Central Vein Sign for MS Diagnosis and Differential Diagnosis

NCT04369898

CompletedN/A

Sponsor: University Hospital, Basel, Switzerland

Conditions: Multiple Sclerosis)

Interventions: Image analysis/ Central vein detection, Image analysis/ Automatic cortical lesion detection

Countries: Switzerland

This study investigates the specificity/sensitivity of the combined presence of cortical lesions (CLs)/leuco-cortical lesions (LCLs) and central veins sign (CVs) for multiple sclerosis (MS) diagnosis and differential diagnosis.

Eligibility overview

Sex: ALL

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Clinical and MRI data of patients with MS or MS mimics (migraine, vasculitis, diabetes, neuromyelitis optica spectrum disorder)
* MRI data must have been collected at 3T between 1990 and 2020 and must include T1 w, T2 w, T2-star based sequence (CVs detection) and DIR/PSIR/MP2RAGE (eventually also high spatial resolution MPRAGE) for cortical lesion detection

Exclusion Criteria:

* Unavailability of institutional informed consent
* Unclear diagnosis
* Other neurological or psychiatric diseases.

Locations (1)

Basel, Switzerland