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Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk
Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk

NCT04346784

CompletedNA

Sponsor: Hunan Normal University

Conditions: Depressive Symptoms, Remited Major Depressive Disorder

Interventions: positive emotion working memory(PEWM) training, negative emtion working memory(NEWM) training, PABT, placebo (NABT)

Countries: China

The goal of this clinical trial is to learn if intervention of positive emotion working memory (PEWM), or negative emotion working memory (NEWM), or positive attention bias training (PABT) can prevent major depressive disorder (MDD) for the long-term effects of intervention in youth with depressive symptoms or with remitted MDD. The main questions it aims to answer are: * Does intervention PEWM, NEWM or PABT lower the MDD onset in youth with depressive symptoms or with remitted MDD? * How long does the intervention PEWM, NEWM or PABT can lower the MDD onset when taken an initial training added one booster training? * Which cognitive factors can predict MDD onset? Researchers will compare PEWM, NEWM, PABT to a placebo (a training that contains no active component) to see if the interventions work to prevent MDD. Participants will: * Take a PEWM, or a NEWM, or a PABT or a placebo nearly every day for 2 weeks with 10 sessions at initial. * Take a PEWM, or a NEWM, or a PABT or a placebo the day after tomorrow for 2 weeks with 8 sessions at 6 months follow-up. * Be interviewed by clinicians with standardized diagnostic schedules for affective disorders and schizophrenia for 5 years * Answer survey questions about depression-related symptoms for 5 years.

Eligibility overview

Sex: ALL

Age: 16 Years to 21 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Scores of the Beck Depression Inventory-II version (BDI-II) of a participant are equal to or more than 14.

Exclusion Criteria: A participant with

* A current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder;
* Any concurrent psychotherapy;
* Any concurrent psychotropic medication.
Locations (1)
  • Changsha, Hunan, China