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Evaluation of the Impact of Lesions of the Motor and Proprioceptive Brain and Pan-medullary Pathways on Their Clinically and Electrophysiologically Assessed Function in Multiple Sclerosis

NCT04220814

CompletedNA

Sponsor: Rennes University Hospital

Conditions: Multiple Sclerosis, Relapsing-Remitting

Interventions: MRI, Electrophysiology

Countries: France

Multiple Sclerosis (MS) is the most common acquired neurological disease leading to disability, especially ambulatory, in young adults. To date, the correlation between the number or volume of white matter lesions seen on conventional MRI and the degree of disability of patients remains low to moderate. This phenomenon is known as the "clinical-radiological paradox". In this new project, we hypothesize that an evaluation of the corticospinal pathways including their thoracic medullary portion, as well as taking into account the severity of the lesions using quantitative MRI, will allow the investigators to refine the correlation with ambulatory disability in MS patients. We will complete the evaluation of motor pathways with those of the proprioceptive pathways also strongly involved in ambulation.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

Patients :

* More than 18 years old
* relapsing-remitting multiple sclerosis according to Mac Donald criteria (2010)
* EDSS score at the inclusion from 0 to 4
* With at least 1 symptom of pyramidal injury during clinical exam
* Written informed consent
* Affiliated to a Health Care system

Healthy Volunteers:

* More than 18 years old
* Written informed consent
* Affiliated to a Health Care system

Exclusion Criteria:

Patients

* progressive MS ;
* Corticoids during the last 60 days before inclusion ;
* Other neurological disease or Other progressive systemic disease
* adults subject to legal protection or persons deprived of liberty
* Contraindications to MRI
* Contraindications to motor evoked potentials
* Current pregnancy or breast-feeding

Healthy volunteers:

* History of disease affecting central nervous system
* Familial history of MS
* History of medullar injury
* Spinal osteoarthritis which can lead to a spinal hypersignal ;
* adults subject to legal protection or persons deprived of liberty
* Contraindications to MRI
* Contraindications to motor evoked potentials
* Current pregnancy or breast-feeding

Locations (2)

Marseille, France
Rennes, France