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The Effectiveness and Safety of Resective Epilepsy Surgery for TRE

NCT04198181

Active Not RecruitingN/A

Sponsor: Beijing Children's Hospital

Conditions: Tuberous Sclerosis Complex, Epilepsy

Interventions: Surgery

Countries: China

A prospective cohort studies to identify clinical seizure control, cognitive changes, and safety in resective epilepsy surgery in patients with TSC-related drug-resistant epilepsy.

Eligibility overview

Sex: ALL

Age: 2 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* 2 years old and above, no gender restriction, TSC gene monitoring with or without abnormality
* Diagnosis of tuberous sclerosis- related drug-resistant epilepsy
* Epilepsy course for more than 1 year
* Patients who have taken 3 or more reasonable choices with appropriate and tolerable antiepileptic drugs (excluding mTOR inhibitors and traditional Chinese medicine and prescriptions) had seizures more than 12 times in the 3 months before enrollment
* The family members agreed to enroll and signed the informed consent.

Exclusion Criteria：

* Obvious renal angiomyolipoma, pulmonary lymphoma leiomyomatosis, and subventricular giant cell astrocytoma
* Abnormal heart, lung, liver, and kidney functions and coagulation function
* Preoperative evaluation, it is considered that no surgical treatment is needed
* The patient received other craniocerebral surgical treatment within 1 year during the follow-up period

Locations (1)

Beijing, Beijing Municipality, China