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Skeletal Muscle Energetics and Fatiguability in Older Individuals

NCT04142047

RecruitingN/A

Sponsor: Johns Hopkins University

Conditions: HIV, HIV Infections

Countries: United States

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Eligibility overview

Sex: ALL

Age: 60 Years to 90 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Participants who are \>= 60 years of age
* HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
* HIV serostatus negative participants

Exclusion Criteria:

* Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
* Contraindications to MRI
* Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
* Significant lower extremity peripheral vascular disease.
* Weight greater than 350 lbs
* Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

Locations (1)

Baltimore, Maryland, United States