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Sponsor: VA Office of Research and Development
Conditions: HIV Infection
Interventions: exercise training
Countries: United States
Most Veterans living with HIV are 50 years of age or older and can expect to live more than 20 years longer with HIV medication. However, despite this success, Veterans living with HIV are more likely to have age-related diseases and loss of fitness and muscle that place them at increased risk for disability. This is a major priority for the VHA, the largest provider of HIV care in the United States. The goal of this study is to test a circuit exercise program in Veterans living with HIV that is designed to slowdown the aging process. The exercise program will be widely available by Video Teleconferencing (VTEL) and does not require stationary exercise equipment, making it widely accessible. This research will help reach the goal for Veterans to preserve their quality of life and ability to function independently. Novel findings will strengthen strategies to maintain life-long fitness through a personalized exercise prescription.
Sex: ALL
Age: 50 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Veteran living with HIV and under care at VAMC * 50 years of age and older * Stable antiretroviral therapy (same ARV medications within 3 months) * At least one HIV-1 PCR \< 20 c/ml (viral load) within prior 6 months Exclusion Criteria: * History of AIDS defining illnesses (within 6 months; CDC Criteria) * Myocardial infarction (within 3 months) * Exertional or unstable angina (current chest pain that limits activity) * Severe congestive heart failure (EF \< 20% in last year or NYHA Classification III or IV) * Uncontrolled hypertension (SBP \>180 \&/or DBP \> 110 mm Hg) * Therapy with beta blockers or non-dihydropyridine calcium channel blocker (within 1 month) * Screening EKG with ischemia, complex arrhythmia, or high-grade block (per Minnesota Code) * Poorly controlled DM within prior 1 month (FBS\>180 mg/dl, RBS \> 299 mg/dl, or HbA1C \> 10) * Receiving treatment for cancer except skin cancer (within 3 months) * Peripheral vascular disease with claudication * Severe arthritis limiting ambulation * Neurologic disease limiting ambulation (requiring assist device) * End stage liver disease (decompensated liver disease) * Chronic renal failure (requiring dialysis) * Severe pulmonary disease (home O2, admission for dyspnea or pneumonia within 1 month) * Use of systemic steroids (testosterone or glucocorticoids) or growth hormone (within 6 months) * Dementia (based on Evaluation to Consent) * Signs or symptoms of any medical comorbidity that would preclude exercise testing or training * Exercise on routine basis (structured aerobic exercise \> 3 times per week) within 1 month * Past medical history of COPD or emphysema AND mMRC score =4
- Decatur, Georgia, United States
- Baltimore, Maryland, United States
- Salem, Virginia, United States