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Senofilcon A Lenses in Moderate to Severe Dry Eye Disease

UnknownNA

Sponsor: University of Illinois at Chicago

Conditions: Moderate to Severe Dry Eye Disease

Interventions: Senofilcon A contact lens

Countries: United States

A clinical trial using Senofilcon A daily lenses in the treatment of moderate to severe dry eye. This a comparison between signs and symptoms prior to and during treatment.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Confirmed diagnosis of moderate to severe dry eye associated with either Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal limbal cell deficiency
* A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes without anesthesia
* Have a visual analog score for comfort of 50 or less (scale of 1-100, with 100 meaning perfect ocular comfort and 1 meaning severe ocular pain)
* Ability or the resources to insert and remove the study lenses
* An OSDI score greater than 42
* A willingness to sign an informed consent

Exclusion Criteria:

* No dry eyes or mild dry eyes
* A baseline Schirmer tear test (1) of greater than 5 mm of wetting at 5 minutes
* Dry eye comfort score of greater than 50 on a visual analog scale
* Unable to insert or remove the study lenses (or have a family member do so)
* Have an OSDI score less than 42
* Has been diagnosed with neurotrophic keratopathy in either eye
* Unwilling to enroll in the study, and unwilling to provide signed informed consent to participate in the study

Locations (1)

Chicago, Illinois, United States