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Acne Vulgaris Related Microbiology and Serology

CompletedN/A

Sponsor: Sanofi

Conditions: Acne Vulgaris

Interventions: Study of humoral immunity

Countries: United States

This will be an investigation to determine the quality of the serological immune responses against Propionibacterium acnes (P. acnes) in acne patients compared to healthy individuals. In particular, the investigators will measure serum antibody titers against P. acnes surface antigens, and the efficiency of antibody-mediated phagocytic killing of P. acnes.

Eligibility overview

Sex: ALL

Age: 18 Years to 40 Years

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Acne patients (18 - 40 years of age)
* Clinical diagnosis of medium acne vulgaris (covering more than 30% of the patient's face and loaded with comedones, pustules and acne lesions of \>2 cm in size) for at least six months or longer
* Clinical diagnosis of severe acne vulgaris (acne conglobata, sinus or cystic type acne covering most of the face (\>60% of the facial surface) - IGA 3-4) for at least six months or longer
* Age-matched healthy adults (between 18 and 40 years), with history of moderate or severe acne, but who have been free from acne for more than two years - 'free from acne' period may include minor, intermittent breakouts due to hormonal reasons, such as menstruation

Exclusion Criteria:

* Subjects who received anti-acne antibiotic therapy less than 2 months prior to recruitment
* Subjects who received isotretinoin therapy within the last 6 months
* Subjects who were using hormonal contraceptives within the last 3 months

Locations (1)

Norfolk, Virginia, United States