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Task Shifting to Treat Depression and HIV Medication Nonadherence in Low Resource Settings

CompletedNA

Sponsor: King's College London

Conditions: HIV Infections, Depression

Interventions: Stepped care for nonadherence and depression, Enhanced Usual Care

Countries: Zimbabwe

A hybrid effectiveness-efficacy trial to evaluate a stepped care task shifted intervention to treat depression and HIV medication nonadherence in low resource settings in rural Zimbabwe.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Initiated on ART for at least 6 months
* Clinically significant depression symptoms scoring \>/= 10 on the Patient Health Questionnaire-9
* Viral non-suppression in past two months per local clinic standard (VL \> 1000 copies/mL)
* Able to provide informed consent
* If prescribed antidepressants, on stable regimen for at least 2 months

Exclusion Criteria:

* Unable to provide informed consent
* Active major mental illness (e.g. untreated psychosis or mania, actively suicidal), major untreated or undertreated mental illness or advanced physical disease or severe cognitive impairment assessed using the psychosis module of the MINI, the PHQ-9, and the International HIV dementia Scale which would interfere with engagement in PST-AD
* Has ever received PST or CBT for depression
* Less than 18 years of age

Locations (1)

Marondera, Mashonaland East Province, Zimbabwe