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Imaging to Improve Brain Stimulation

CompletedN/A

Sponsor: VA Office of Research and Development

Conditions: Depressive Disorder

Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS)

Countries: United States

This study investigates how brains change as a result of a treatment for depression called repetitive transcranial magnetic stimulation (rTMS). People who receive rTMS will have pictures of their brains and brain activity taken by a magnetic resonance imaging (MRI) scanner before and after their treatment, as well as up to three times during the six-week treatment course. These images will be examined to see if the rTMS is placed correctly to help treat their symptoms, and what changes in brain activity are happening during the rTMS treatment

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Veteran beginning TMS therapy for the treatment of MDD at the Providence VAMC Neuromodulation Clinic
* Age between 18 and 80 years
* Able to read, verbalize, understand, and voluntarily sign the informed consent form
* Structured Clinical Interview for DSM-5 (SCID-5) confirmed diagnosis of MDD

Exclusion Criteria:

* Contraindications to MRI (e.g. implanted metal or electronic devices)
* Montreal Cognitive Assessment (MoCA) score \< 26
* Pregnant

Locations (2)

Palo Alto, California, United States
Providence, Rhode Island, United States