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Sponsor: Assistance Publique - Hôpitaux de Paris
Conditions: Pancreatic Cancer
Interventions: MRI with additional sequences, MRI, Left pancreatectomy or pancreaticoduodenectomy, MRI with additional sequences
Countries: France
Obesity, diabetes and metabolic syndrome (MS) have all been associated with increase of pancreatic cancer (PK) risk. The precise role of obesity and diabetes and the pathways involved in the early oncogenic phases of PK associated with MS are not well known. The investigators hypothesize that it is possible to decipher this specific "fat-fibrosis-neoplastic sequence", to develop new imaging tools adapted to follow its progression, to test the benefit of treatments to slow this sequence and prevent the development of PK in obese and diabetic patients.This project is in line with a prevention strategy, by planning to understand the physiopathological pathways involved in MS leading to PK, to develop tools useful to screen early precancerous lesions in order to diagnose and treat patients at high risk, before cancer involvement. This clinical trial is part of the INCA PAIR PANCREAS project : Early stages of pancreatic cancer associated with obesity and metabolic syndrome: prevention and screening tools - Imaging of fatty pancreas in humans: correlation with pathological analysis, which includes 3 main coordinated objectives an in vitro approach an in vivo approach and this study (clinical approach).
Sex: ALL
Age: 18 Years to —
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: * 1st stage : Volunteers without history of known pancreatic disorders \- Adults * 2nd stage : Obese Volunteers * Adults with planned hepatic MRI * Obese (BMI ≥30) * 3rd stage : Patients * Adults (aged 18-65 years) with a planned pancreatic surgery for benign pancreatic lesions (IPMN, cystic lesions or neuroendocrine tumors) * Obese (BMI≥30), overweight (25≤BMI≤29.9) or non-obese patients (18.5\<BMI\<24.9) Exclusion Criteria: For volunteers without history of known pancreatic disorders (1st stage): \- Symptoms or past medical history suggesting pancreatic disorders For all participants (1st, 2nd and 3rd stages) : * Patients with contraindication to MRI (pacemaker, claustrophobia…) * Inability to undergo MRI due to weight excess * Pregnant or breastfeeding woman * Absence of free and informed consent * Non affiliation to a social security regime or CMU * Subject deprived of freedom, subject under a legal protective measure
- Clichy, France