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Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis

CompletedNA

Sponsor: University of Missouri, Kansas City

Conditions: Multiple Sclerosis

Interventions: Neuropsychological Feedback & Psychoeducation (Cognition), Psychoeducation (Health)

Countries: United States

Multiple sclerosis (MS) is among the most prevalent autoimmune diseases among young and middle-aged adults. Up to 65% of MS patients experience objective cognitive impairment including problems with information processing speed, memory, and executive functioning. However, patients commonly overestimate the extent of their cognitive dysfunction which can result in inaccurate perceptions of their true cognitive abilities. Exaggerated perceptions of cognitive impairment are predictive of future decline and associated with depression, anxiety, and reduced quality of life. Despite this, no study has examined an intervention aimed at changing misperceptions related to perceived cognitive impairment in MS when objective measures are incongruent with self-reported cognitive symptoms. The purpose of the present study is to develop and pilot a brief intervention for MS patients who perceive cognitive impairment, but perform in the normal or expected range on objective measures of cognition.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* diagnosis of MS by a board-certified neurologist
* a total score \> 40 on the Perceived Deficits Questionnaire (PDQ) based on previous research that identifies this cutoff score as clinically significant in the MS population and two standard deviations below average in the general population (Ruth Ann Marrie, Gordon J. Chelune, Deborah M. Miller, \& Jeffrey A. Cohen, 2005)
* score in the low average or better range on the Wechsler Test of Adult Reading (WTAR)
* average score equal to or greater than the 16th percentile on the Hopkins Verbal Learning Test (HVLT), Symbol Digit Modalities Test (SDMT), Controlled Oral Word Association Test (COWAT), and Wisconsin Card Sorting Task (WCST)
* average T score on the HVLT, SDMT, COWAT, and WCST no more than one standard deviation below the WTAR T score
* access to a computer and a personal email account
* English-speaking

Exclusion Criteria:

* no severe sensory, motor, physical, or neurological impairment that would make participation in the study insurmountable
* no history of nervous system disorder other than MS

Locations (1)

Kansas City, Kansas, United States