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Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype

CompletedNA

Sponsor: University of North Carolina, Greensboro

Conditions: Healthy, Dementia, Alzheimer Disease, Physical Activity

Interventions: Physical Activity Condition

Countries: United States

Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive performance by persons at the greatest risk of Alzheimer's disease.

Eligibility overview

Sex: ALL

Age: 40 Years to 65 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Family History of Alzheimer's disease, cognitive impairment
* Able to communicate in English
* Not currently meeting recommendations for physical activity (the recommendations are to exercise 3 days/week for 30+ minutes per day for longer than 3 months)
* Willing to be randomized to either study condition
* Willing to complete all study activities for 1 year

Exclusion Criteria:

* Meet the criteria for clinical cognitive impairment
* Unable to perform physical activity due to known cardiovascular, metabolic, or renal disease and are symptomatic or due to orthopedic limitations
* Self-report history of confounding neurologic, psychiatric, or active severe or functionally disabling neurologic or medical diseases, or any other conditions that might limit exercise or pose a danger to the patient
* Current use of medications to treat symptoms of Alzheimer's disease, that adversely affect cognition, or that impact heart rate
* Meet the criteria for depression using the short form of the Center for Epidemiological Studies Depression Scale
* Traveling for an extended period (\>1 month) during the course of the study

Locations (1)

Greensboro, North Carolina, United States