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Immediate ART in Subjects With Opportunistic Diseases

CompletedNA

Sponsor: Gustavo Reyes-Teran

Conditions: HIV/AIDS, ANTIRETROVIRAL TREATMENT

Interventions: Antiretroviral Therapy (ART), Antiretroviral Therapy (ART)

Countries: Mexico

The aim of this study is to compare the clinical response and mortality rate due to opportunistic disease in HIV-infected individuals who start immediate versus conventional antiretroviral therapy (ART). Immediate ART (iART) is defined as starting antiretroviral therapy within the first 48 hours after hospitalization. Conventional ART (cART) is defined as starting antiretroviral therapy once the opportunistic infection is under control at the discretion of the infectious disease specialist.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* HIV infection documented by ELISA or rapid test.
* Age 18 years or older.
* Hospitalized at the emergency department, intensive care unit, or clinical pulmonology ward of the National Institute of Respiratory Diseases (INER) with clinical criteria of an opportunistic infection or AIDS-related malignancy.
* Candidate to initiate first ART regimen or presenting with first- or second-line ART failure.
* ART-naïve or with ART discontinuation for at least 3 months prior to enrollment.

Exclusion Criteria:

* Diagnosis or clinical symptoms suggestive of cryptococcal meningitis, tuberculous meningitis, or meningitis of any other cause.
* Pregnant women.
* Admitted exclusively for treatment of neurosyphilis without any other active opportunistic infection.

Locations (1)

México, State of Mexico, Mexico