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Sponsor: University Hospital, Lille
Conditions: Multiple Sclerosis
Countries: France
Recent works highlight the B cells involvement in multiple sclerosis (MS) pathology but their role remains poorly understood. It was previously described that activated memory B cells called 4BL due to the increased expression of 4-1BBL, an activation marker, induce pro-inflammatory response by activating T CD8+ lymphocytes. Those 4BL cells are also described in systemic inflammation in 80 years old people explaining the poor efficiency of vaccination in that sub population. Those 4BL cells can also induce anti-tumoral T cell response. The hypothesize is that 4BL may induce a pathogenic inflammatory response in MS.
Sex: ALL
Age: 18 Years to 60 Years
Healthy volunteers: Yes
Study type: OBSERVATIONAL
Inclusion Criteria for MS group: * MS defined by McDonald 2017 criteria with a disease duration of less than 1 year * between 18 and 60 years old patients * naïve of any immune therapy or steroid intake * patients who signed consent to the study Inclusion Criteria for controls with inflammatory of non inflammatory neurological disease: * patients who signed consent to the study * between 18 and 60 years old patients * naïve of any steroid intake or immune therapy Inclusion criteria for healthy controls: * control who signed consent at transfusion center for their blood collect to be used for study * between 18 and 60 years old patients * naïve of any steroid intake or immune therapy Exclusion Criteria: * pregnancy or breast-feeding * patients or controls unable to sign the consent or to consent
- Lille, France