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Inclusion criteria:

* General criteria
* Patient, of 18 and more years old
* Subject affiliated to a social security system
* Subject not being in period of exclusion with regard to another protocol
* Absence of pregnancy in the inclusion (date of the last period, use of a contraceptive method, ß -HCG impulsive person in case of doubt)
* Informed consent
* Criteria of inclusion of the group rheumatoid arthritis (in vitro studies):
* Rheumatoid arthritis, corresponding to the the classification ACR / EULAR 2010 criteria
* Criteria of inclusion of the group arthritis (in vitro studies):
* Spinal degenerative osteoarthritis or degenerative osteoarthritis of the members, according to the clinical and radiological elements.
* Criteria of inclusion of the group rheumatoid arthritis, longitudinal study at the patients treated by JAK / STAT inhibitors :
* Rheumatoid Polyarthritis, corresponding to the classification ACR / EULAR 2010 criteria
* Patient to whom a treatment by inhibitor of the way JAK / STAT was proposed in current care of rheumatoid arthritis.

Exclusion criteria:

* General criteria
* Corticosteroid therapy superior to 10 mg / j
* Drip of corticoids in the previous month
* Pregnant or breast-feeding Patients
* Patient under protection(saving) of justice
* Under guardianship Patient or guardianship
* Current Infection
* Criteria of non-inclusion of the group rheumatoid polyarthritis ( in vitro studies):
* Treatment by immunomodulateur or biotherapics (anti-TNF alpha, tocilizumab, abatacept or rituximab) in the previous year
* Criteria of non-inclusion of the group arthritis ( in vitro studies):
* History of autoimmune disease or néoplasie
* Treatment by immunomodulateur or biotherapics (anti-TNF alpha, tocilizumab, abatacept or rituximab)
* Criteria of non-inclusion of the group rheumatoid arthritis, longitudinal study at the patients treated by JAK / STAT inhibitors :

Treatment by rituximab in the previous year

• Montpellier, France