NCT lookup

Pull any trial record directly from ClinicalTrials.gov.

B Cell Differentiation in MS

NCT03744351

CompletedNA

Sponsor: Rennes University Hospital

Conditions: Multiple Sclerosis

Interventions: Biological Samples, Biological Samples, Biological Samples, Biological Samples

Countries: France

Interventional study with minimal risks and constraints, prospective, monocentric.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

Regarding MS patients (remitting or progressive untreated):

* Adult (age greater than or equal to 18 years) of both sexes;
* MS fulfilling the criteria of McDonald 2017;
* Remittent or progressive form;
* No immunomodulatory or immunosuppressive therapy for at least 3 months;
* Free, informed and written consent signed by the patient.

Regarding Clinically Isolated Syndrome:

* Adult (age greater than or equal to 18 years) of both sexes;
* Clinically isolated syndrome suggestive of MS (at least two typical lesions in two different locations);
* Patient receiving a Lumbar Puncture (PL) for diagnostic purposes;
* No immunomodulatory or immunosuppressive therapy for at least 3 months;
* Free, informed and written consent signed by the patient.

Regarding non-MS patients with neurological inflammatory disease:

* Adult (age greater than or equal to 18 years) of both sexes;
* Patient with non-MS neurological inflammatory disease (examples: meningitis, neurolupus, neurosarcoidosis...);
* Patients with PL for diagnostic or surveillance purposes;
* No immunomodulatory or immunosuppressive therapy for at least 3 months;
* Free, informed and written consent signed by the patient.

Regarding healthy volunteers:

* Adult (age greater than or equal to 18 years) of both sexes;
* Free, informed and written consent signed by the volunteer.

Exclusion Criteria:

Regarding all patients:

* Pregnancy;
* Breastfeeding;
* Treatment with corticotherapy in the last month;
* Patient not affiliated to social security;
* Persons major subject to legal protection (safeguard of justice, guardianship, tutorship), persons deprived of their liberty.

Regarding healthy volunteers:

* Pregnancy;
* Breastfeeding;
* Not affiliated to social security;
* Persons major subject to legal protection (safeguard of justice, guardianship, tutorship), persons deprived of their liberty.

Locations (1)

Rennes, France