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A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis
A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis

NCT03737812

CompletedPhase 2

Sponsor: AbbVie

Conditions: Multiple Sclerosis (MS)

Interventions: elezanumab, placebo

Countries: United States, Canada

The purpose of this study is to evaluate the safety and efficacy of elezanumab in participants with progressive Multiple Sclerosis (PMS).

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Diagnosis of primary-progressive multiple sclerosis (PPMS) or non-relapsing secondary-progressive multiple sclerosis (SPMS) and no relapses for at least 24 months.
* Evidence of physical disability according to Expanded Disability Status Scale (EDSS) or Timed 25-Foot Walk (T25FW) or 9-Hole Peg Test.

Exclusion Criteria:

* Treatment with any of the following within the 6 months prior to Screening: natalizumab; cyclosporine; azathioprine; methotrexate; mycophenolate mofetil; intravenous immunoglobulin (IVIg); any interferon product; and intravenous (IV), oral, or intrathecal corticosteroids for the purposes of disease modification.
* Treatment with the following within 1 year prior to Screening: cyclophosphamide or alemtuzumab.
Locations (37)
  • Phoenix, Arizona, United States
  • Berkeley, California, United States
  • Carlsbad, California, United States
  • Hanford, California, United States
  • Palo Alto, California, United States
  • Sacramento, California, United States
  • San Francisco, California, United States
  • Aurora, Colorado, United States
  • Fort Collins, Colorado, United States
  • Lenexa, Kansas, United States
  • Baltimore, Maryland, United States
  • Lutherville, Maryland, United States
  • Farmington Hills, Michigan, United States
  • Owosso, Michigan, United States
  • Chaska, Minnesota, United States
  • St Louis, Missouri, United States
  • St Louis, Missouri, United States
  • Las Vegas, Nevada, United States
  • Oklahoma City, Oklahoma, United States
  • Portland, Oregon, United States
  • Franklin, Tennessee, United States
  • Franklin, Tennessee, United States
  • Dallas, Texas, United States
  • Round Rock, Texas, United States
  • Alexandria, Virginia, United States
  • Kirkland, Washington, United States
  • Seattle, Washington, United States
  • Seattle, Washington, United States
  • Morgantown, West Virginia, United States
  • Milwaukee, Wisconsin, United States
  • + 7 more on CT.gov