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Efficacy of Treatment Sequences in Patients With Non-small Cell Lung Cancer Receiving Lorlatinib

CompletedN/A

Sponsor: Intergroupe Francophone de Cancerologie Thoracique

Conditions: Non-small Cell Lung Cancer Metastatic, ALK Gene Rearrangement Positive, ROS-1 Gene Rearrangement Positive

Countries: France

The study will evaluate progression-free survival, overall survival, best response and duration of treatment in patients with advanced ALK- and ROS1-positive non-small cell lung cancer who received lorlatinib as part of the French expanded access program.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patients with histologically or cytologically confirmed locally advanced or metastatic NSCLC (Stage IIIB or IV accordingly to American Joint Committee on Cancer \[AJCC\] classification) at time of lorlatinib initiation
* Patients who received at least one week of treatment with lorlatinib as part of the French Expanded Access Program (ATU program); ATU was granted due to their inability to meet eligibility criteria for on-going recruiting trials, inability to participate in other clinical trials (e.g., poor performance status, lack of geographic proximity), or because other medical interventions are not considered appropriate or acceptable.

Exclusion Criteria:

* Patients enrolled in a lorlatinib clinical trial

Locations (30)

Aix-en-Provence, France
Angers, France
Annemasse, France
Avignon, France
Bordeaux, France
Brest, France
Cahors, France
Chartres, France
Clermont-Ferrand, France
Colmar, France
Créteil, France
La Roche-sur-Yon, France
Libourne, France
Lorient, France
Lyon, France
Marseille, France
Montpellier, France
Mulhouse, France
Paris, France
Paris, France
Paris, France
Pierre-Bénite, France
Reims, France
Saint-Etienne, France
Saint-Nazaire, France
Toulouse, France
Tours, France
Valenciennes, France
Vandœuvre-lès-Nancy, France
Villejuif, France