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Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation

CompletedNA

Sponsor: Sunnybrook Health Sciences Centre

Conditions: Multiple Sclerosis, Primary Progressive, Cognitive Impairment

Interventions: Cognitive Rehabilitation, Sham Exercise, Sham Cognitive Rehabilitation, Aerobic Exercise

Countries: Canada

Given that up to 70% of people with secondary progressive MS are cognitively impaired, the search for effective treatments is considered a priority by people living with the disease. This proposal will address the effectiveness of cognitive rehabilitation (CR) and exercise, either alone, or in combination in this regard. A team of MS researchers has been assembled from the USA, Canada, the United Kingdom, Italy, Denmark, Germany and Belgium for this. A total of 360 people with progressive MS will make up the sample. Brain MRIs will be undertaken in a third of the sample before and after the 12 weeks of treatment to document the functional changes that are expected to occur with symptom improvement.

Eligibility overview

Sex: ALL

Age: 25 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Have a confirmed diagnosis of progressive Multiple Sclerosis
* Visual Acuity of 20/70
* Language comprehension, to ensure subjects have the ability to understand instructions

Exclusion Criteria:

* Wheelchair dependent (EDSS \> 7.0)
* History of central nervous system disease other than progressive MS
* Steroids use within the past 3 months
* Regular aerobic training (eg. bi-cycling, running, swimming or rowing)
* Unwilling to travel to study sites for rehabilitation 2 times a week for 3 months

Locations (1)

Toronto, Ontario, Canada