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Validation of Multimodal Evoked Potentials (mmEP) for Predicting Disease Progression in Multiple Sclerosis

CompletedN/A

Sponsor: University Hospital, Basel, Switzerland

Conditions: Multiple Sclerosis

Interventions: multimodal evoked potentials (mmEP)

Countries: Switzerland

Utility of Multimodal Evoked potentials (mmEP) for monitoring disease course and prediction of progression at different stages of Multiple Sclerosis (MS) is investigated

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* diagnosed with a clinically isolated syndrome (CIS) or MS with a relapsing-remitting (RRMS) or a primary progressive disease course (PPMS):
* CIS: EDSS \<= 5.5 within six months of first clinical event
* early RRMS: EDSS: \<= 3.5 disease course of 5 up to 10 years
* late RRMS: EDSS: 2.0-5.5 inclusive disease course of 5 to 15 years
* PPMS: EDSS: 2.0-6.5 inclusive disease course up to 15 years
* participation in the Swiss Multiple Sclerosis Cohort Study (SMSC)
* mental ability to cooperate
* written informed consent

Exclusion Criteria:

* alcohol or substance abuse
* progressive disease other than Multiple Sclerosis
* psychiatric disorder requiring a treatment by a psychiatrist
* patients with movable metal implants, e.g. pace-maker, stents, deep brain stimulators etc.;(patients with jaw- or bone-fixed metal implants can be included)

Locations (3)

Basel, Switzerland
Geneva, Switzerland
Lugano, Switzerland