NCT lookup
Pull any trial record directly from ClinicalTrials.gov.
Sponsor: Washington University School of Medicine
Conditions: HIV
Interventions: Imaging, Serum Laboratory Tests, Lumbar Puncture
Countries: United States
The purpose of this research study is to look at the brain's efficiency and ability to make up for deficits in the front of the brain to see if people living with HIV (PLWH) are still able to perform well on various cognitive tasks even though there are other underlying processes at work, like inflammation, that affect the brain in a negative way. Results of this study may provide insight into the pathophysiology of disease and may reveal arenas for future possible interventions in PLWH who have impaired neuropsychological performance.
Sex: ALL
Age: 20 Years to 80 Years
Healthy volunteers: Yes
Study type: OBSERVATIONAL
Inclusion Criteria: * 20 to 80 years old * documented HIV infection for at least 1 year or confirmed HIV - status * PLWH must be on stable cART regimen for at least 12 months with undetectable plasma HIV RNA (less than 50 copies per mL) * at least 9 years of education * able to provide informed consent * if female, a negative pregnancy test and not breast feeding * able to undergo an MRI scan Exclusion Criteria: * significant neurological disorders (e.g. stroke, head injury with loss of consciousness for more than 5 minutes, developmental learning disability) * active uncontrolled Axis I psychiatric disorder according to the DSM 5 * current or history of substance use disorder (including, but not limited to amphetamines, cocaine, alcohol, opiates, and barbiturates) * prescribed blood thinners * allergic to lidocaine or similar anesthetic * history of any bleeding disorder * contraindication to MRI scanning (e.g. claustrophobia, pacemaker, etc.) * pregnant or breastfeeding
- St Louis, Missouri, United States