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Phosphodiesterase 4 Gene Variant and Salbutamol Response in Persistent Childhood Asthma

TerminatedN/A

Sponsor: Assistance Publique - Hôpitaux de Paris

Conditions: Asthma

Interventions: Salbutamol

Countries: France

This study is designed to investigate whether the Phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.

Eligibility overview

Sex: ALL

Age: 6 Years to 18 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Children 6-18 years
* Asthma: confirmed asthma symptoms (wheeze, cough, dyspnea, chest tightness) and evidence for variable airflow limitation (≥ 12% increase in post bronchodilator FEV1, or ≥ 20% decrease in FEV1 post methacholine)
* Spirometry prescribed for follow-up
* Airflow limitation: FEV1\<80% and/or FEV1/FVC \<80 pre-bronchodilator

Exclusion Criteria:

* no exclusion criteria

Locations (1)

Paris, France