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Subthalamic Steering for Therapy Optimization in Parkinson's Disease

CompletedNA

Sponsor: University Hospital Tuebingen

Conditions: Parkinson Disease

Interventions: Omnidirectional Deep Brain Stimulation of STN, Directional Deep Brain Stimulation of STN

Countries: Germany

Twenty patients with idiopathic Parkinson's disease (PD) will be included into this single center randomized controlled double-blind clinical trial (RCT) in a cross-over design. The treatment consists of two different stimulation settings using (i) conventional omnidirectional stimulation of the subthalamic nucleus \[STN\_O\] as active comparator and (ii) directional steering of STN stimulation via a segmented electrode contact \[STN\_D\].

Eligibility overview

Sex: ALL

Age: 18 Years to 80 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Written informed consent
* Idiopathic Parkinson's disease (according to the "British Brain Bank criteria" (Hughes, 1992) including genetic forms

Exclusion Criteria:

* Cognitive impairment (Mini Mental State Exam \< 20)
* Suicidality, Psychosis
* Other severe pathological chronic condition that might confound treatment effects or interpretation of the data
* Pregnancy

Locations (1)

Tübingen, Baden-Wurttemberg, Germany