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Dietary Phytoestrogens as Risk Factors for Systemic Lupus Erythematosus

CompletedNA

Sponsor: University Hospital, Bordeaux

Conditions: Lupus Erythematosus, Rheumatoid Arthritis, Autoimmune Thrombocytopenia

Interventions: blood sample, urine sample, food questionnaire, hair

Countries: France

The study aims at determining if dietary phytoestrogens can be risk factors for Systemic Lupus Erythematosus (SLE). Dietary enquiry and phytoestrogens measurements will be performed in blood and urine of patients with SLE in an active phase of the disease, in patient with other autoimmune diseases and in healthy volunteers. Subjects will be premenopausal women and when possible at a define stage of the menstrual cycle. Free blood estradiol will be assayed as a confounding risk factor.

Eligibility overview

Sex: FEMALE

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Group : Systemic Lupus Erythematosus :

  * Premenopausal women over 18
  * with acute LEAD flare
  * having given informed consent
  * and being covered by social insurance.
* Group : Autoimmune diseases :

  * Premenopausal women of matching age with other autoimmune disease,
  * having given informed consent
  * and being covered by social insurance.
* Healthy controls :

  * Premenopausal women over 18,
  * having given informed consent,
  * and being covered by social insurance.

Exclusion Criteria:

* Group Systemic Lupus Erythematosus and group autoimmune diseases

  * Human Immunodeficiency virus (HIV), hepatitis C virus (HCV) or hepatitis C virus (HBV) sero-positivity;
  * pregnant or lactating women;
  * menopausal women;
  * patient in remission of quiescent phase of her pathology;
* Healthy controls :

  * HIV, HCV or HBV sero-positivity;
  * pregnant or lactating women;
  * menopausal women.

Locations (1)

Pessac, France