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Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings

CompletedNA

Sponsor: Yale University

Conditions: Opioid Dependence, Addiction, HIV/AIDS, Tuberculosis, Hepatitis

Interventions: Isoniazid, Rifapentine

Countries: Malaysia

The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence. A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR). Investigators will also use this data, and publicly available data to complete agent-based modeling for comparative and cost-effectiveness of various TB screening and treatment strategies among prisoners.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

Inclusion Criteria (screening):

* Age ≥ 18 years
* Newly admitted inmate at Kajang Prison

Inclusion Criteria (Trial):

* Age ≥ 18 years HIV-1 seropositivity
* Confirmed LTBI (TST ≥ 5mm if HIV+; TST ≥ 10 mm if HIV-)
* Meets DSM-V criteria for opioid dependence
* \>9 months before release (to ensure treatment completion in prison)
* AST/ALT \< 3x upper limit normal

Exclusion Criteria:

* Unable to provide informed consent
* On a protease inhibitor
* Women who are pregnant or are planning on becoming pregnant

Locations (1)

Kajang, Selangor, Malaysia