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Sponsor: University of California, San Francisco
Conditions: HIV, Medication Adherence
Interventions: Tel-me-box with reminder features, Tel-me-box
Countries: India
Currently available methods to monitor antiretroviral (ARV) adherence to HIV treatment and prevention, such as self-report, pill counts, medication electronic monitoring system (MEMS), and devices which wirelessly monitor adherence in real-time, have multiple limitations, including over-reporting, inability to assess pill ingestion, and size/expense. Our multidisciplinary research team at the University of California, San Francisco (UCSF) and in India has designed a new adherence-monitoring device called "Tel-Me-Box" which is small, low-cost, rechargeable, inconspicuous, and could be programmed to deliver tailored real-time adherence reminders following additional hardware modifications. The aim of this study is to modify and validate this discreet Tel-Me-Box (TMB) adherence monitoring and reminder device against hair ARV concentrations as a pharmacologic measure of drug ingestion/adherence, a measure pioneered and validated by our team, with the expectation that this device and intermittent hair monitoring could have widespread utility for HIV and non-HIV adherence science, both in India and globally.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * HIV-positive * Currently on antiretroviral therapy (ART) * Speaks one of the local languages * Able and willing to participate in the study, provide informed consent, contact information, and express a willingness to return for follow-up visits every three months for 12 months after baseline. * Adherence-challenged per self-report, i.e. report of \<90% ART adherence or \>2 ART treatment interruptions of at least 2 days in the past 3 months Exclusion Criteria: * Unwilling or unable to participate in the study and/or return for follow-up appointments * younger than 18 years old * Not HIV-infected * Not currently on ART * Does not speak one of the local languages
- Bangalore, Karnataka, India