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Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder

CompletedN/A

Sponsor: The Methodist Hospital Research Institute

Conditions: Multiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder, Detrusor, Overactive, Urge Incontinence

Interventions: Intra-detrusor injection of Onabotulinumtoxin-A

Countries: United States

The purpose of this research study is to evaluate higher neural changes following intra-detrusor injection of Onabotulinumtoxin-A (BTX-A) in patients with Multiple Sclerosis (MS). We will use our prospectively collected cohort of patients. Concurrent Urodynamic and Functional Magnetic Resonance (fMRI) data will be recorded pre- and post-intravesical injection of BTX-A in patients with Multiple Sclerosis (MS) and neurogenic detrusor activity (NDO).

Eligibility overview

Sex: FEMALE

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patients with clinical diagnosis of neurogenic bladder.
* History of any neurologic illness or injury (including but not limited to spinal cord injury, Multiple Sclerosis, spina bifida, Parkinson's, major spine surgery).
* 18 years or older.
* Female patients.

Exclusion Criteria:

* Male
* History of any incontinence surgery (sling, Marshall-Marchetti-Krantz Procedure, Burch).
* History of any lower urinary tract surgery or manipulation (urethral dilation).
* Positive urine pregnancy test at enrollment .

Locations (1)

Houston, Texas, United States